ABSTRACT
To evaluate clinically the efficacy of Zimade Muhasa, a Unani anti acne formulation, for Busoore labaniya [Acne vulgaris] against 5% benzoyl peroxide. The randomized, single-blind, standard controlled trial of 6 weeks evaluated the efficacy and tolerability of Unani topical antiacne formulation against standard control i.e. 5% benzoyl peroxide in 48 patients of either sex on the basis of Global Evaluation of Acne Scale [GEA Scale] along with arbitrary scale for assessment of effect over postinflammatory hyperpigmentation, scarring and fairness. In addition quality of life was assessed according to Cardiff Acne Disability Index [CADI] questionnaire. The alterations in improvement and possible complications were regularly assessed. After 6 weeks of treatment, compared with baseline both the treatment preparations decreased the acne lesions [P<0.001]. Further, the test formulation improved postinflammatory hyperpigmentation [P<0.001], scarring [P=0.025] and complexion [P0.001]. There was significant [P<0.001] improvement in the quality of life in treatment groups at the end of study. The test formulation was well-tolerated and equivalent to 5% benzoyl peroxide in alleviating acne lesions. Test formulation was also more effectual concerning the effects over sears, post inflammatory hyperpigmentation and fairness. This formulation can be used safely to treat active acne as well as in patients with post acne scarring. The clinical relevance may be clarified by longer duration treatment
ABSTRACT
Although acne is described in very ancient writings dating back to Ebers papyrus, its clear description is found after Fuchs coined the term 'Acne vulgaris' and Erasmus Wilson separated it from acne rosacea. The early treatment of acne was based upon the witchcraft. Later new therapies evolved with the discoveries in the field of anatomy, physiology and biochemistry. The following review focuses on the historical overview of acne vulgaris, highlighting persons and discoveries in medieval and modern period.